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pentobarbital will minimize the level or impact of doravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will decrease the level or effect of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Loss of, or reduced response to tofacitinib may well happen when coadministered with powe